NAD as a genotype-specific drug target.
نویسندگان
چکیده
Using high-throughput chemical and genetic screening, Matheny and colleagues (in this issue of Chemistry & Biology) identified STF-118804, an inhibitor of nicotinamide phosphoribosyltransferase, as a cell type-specific inhibitor of mixed-lineage leukemia with MLL chromosomal rearrangements. The approach was powerful, as is the potential for NAD as a specific cancer target.
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ورودعنوان ژورنال:
- Chemistry & biology
دوره 20 11 شماره
صفحات -
تاریخ انتشار 2013